Progressive supranuclear palsy

doi:10.1136/mp.54.6.427

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Molecular Pathology 2001;54:427-434; doi:10.1136/mp.54.6.427

J Clin Pathol: Mol Pathol 2001; 54:427-434
© 2001 Journal of Clinical Pathology

Review

Progressive supranuclear palsy

K Tawana, D B Ramsden

Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK

Correspondence to:
Dr Ramsden D.B.Ramsden{at}bham.ac.uk

This review concentrates on the molecular pathology of the protein ${tau}$ , including its expression in various regions of the brain.The role of post-translational modifications in fibrillogenesisis also discussed, particularly hyperphosphorylation and glycation.However, the initiating event that causes aberrant ${tau}$ processingremains unclear.