Molecular Pathology 2001;54:435; doi:10.1136/mp.54.6.435-a
Copyright © 2001 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists.
J Clin Pathol: Mol Pathol 2001; 54:435
© 2001 Journal of Clinical Pathology
© 2001 Journal of Clinical Pathology
Miscellaneous
Nitric Oxide and the Regulation of the Peripheral Circulation.
Kadowitz PJ, McNamara DB, eds. (£86.00.) Birkhauser, 2000. ISBN 3 7643 4046 0.
In the first chapter of this book, Louis Ignarro gives an overview of the discovery of endothelial control of vascular smooth muscle relaxation (endothelium dependent relaxation; EDRF), and the simultaneous elucidation of the mechanism of action of nitrovasodilators (release of nitric oxide (NO) from glyceryl trinitrate). Ignarro and Salvador Moncada showed by different techniques that EDRF and NO were the same substance. In 2001, NO is recognised as a ubiquitous molecule with multiple functions, but it continues to tease us with therapeutic possibilities rather than actualities. We are still at the edge of understanding with this molecule, and the contents of this book bear this out. Each chapter describes the actions of NO at a particular channel, or on a particular ion, or in a particular vascular bed. All chapters are written by experts in the field and give highly readable overviews of the known effects of NO in that
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