© 2002 Journal of Clinical Pathology
ECHO
What turns neutrophils on
Insoluble and soluble immune complexes in synovial fluid in rheumatoid arthritis activate neutrophils differently, researchers in Liverpool, UK, have found. Immune complexes and neutrophils are abundant in synovial fluid in rheumatoid arthritis, as are cytokines, which can prime neutrophils making them more responsive. Understanding how immune complexes and neutrophils interact, leading to production of tissue damaging enzymes and oxidants, and the molecular control of the interactions are potential keys to new therapeutic treatments.Fossati et al used in vitro chemiluminescence to detect production of oxidants by washed blood neutrophils in their unprimed state or primed with granulocyte-macrophage colony stimulating factor—a cytokine in synovial fluid in rheumatoid arthritis—when incubated with synthetic insoluble or soluble immune complexes. By comparing the reaction kinetics of chemiluminescence with substrates available to the neutrophils either extracellularly or intracellularly and with different specific scavengers of oxidants, they were able to unravel the processes.
Insoluble complexes activated unprimed
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