DNA protein crosslinks and p53 expression are important in defining the danger of exposure to formaldehyde

doi:10.1136/mp.56.6.361

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Molecular Pathology 2003;56:361; doi:10.1136/mp.56.6.361

Molecular Pathology 2003;56:361
© 2003 BMJ Publishing Group Ltd & Association of Clinical Pathologists

ECHO

DNA protein crosslinks and p53 expression are important in defining the danger of exposure to formaldehyde

The first 150 words of the full text of this article appear below.

DNA protein crosslinks (DPC) and mutation in the p53 tumoursuppressor gene may be causally related and represent stepsin the carcinogenicity of formaldehyde (FA). This has importantimplications for workers exposed to the latter.

Formaldehyde resins are used in producing adhesives for wood,plastics, textile, and leather while FA itself is a bactericideand tissue preservative. It is known to be a carcinogen; invitro and in mammalian studies its primary genotoxic effectis the formation of DPC in target tissues but no studies onthe latter had been conducted previously on humans.

The investigators examined DPC in peripheral blood mononuclearcells and p53 in serum from 186 workers in hospital laboratories(‘exposed’) and 213 hospital administrators (‘controls’).

DPC levels were significantly higher in the exposed group andthe mean amount increased with increasing levels of exposureto FA, as determined by ambient air analysis. Additionally FAexposure increased . . . [Full text of this article]