Article Text

PDF

Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer
  1. A M Cantlay,
  2. D Lamb,
  3. M Gillooly,
  4. J Norrman,
  5. D Morrison,
  6. C A D Smith,
  7. D J Harrison
  1. Department of Pathology, Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG
  2. Department of Respiratory Medicine

    Abstract

    Aim—To investigate cytochrome P4501A1 (CYP1A1) polymorphism and susceptibility to emphysema and lung cancer.

    Methods—A novel polymerase chain reaction (PCR) for genotyping the CYP1A1 polymorphism, corresponding to putative low or high enzyme activity, was developed to genotype lung cancer resection samples which had been assessed macroscopically for the presence of centriacinar and panacinar emphysema. Samples were collected and genotyped from a group of patients with chronic obstructive airways disease. A control group of anonymous blood donations was genotyped to determine the basal levels of the polymorphism in the Scottish population.

    Results—The high activity allele of the CYP1A1 gene is associated with susceptibility to centriacinar emphysema and lung cancer but not panacinar emphysema. CYP1A1 polymorphism is not linked to lung cancer in the absence of emphysema, nor to chronic obstructive airways disease which is the clinical manifestation of emphysema, particularly of the panacinar type.

    Conclusions—Susceptibility to emphysema and lung cancer is associated with polymorphism of the P4501A1 gene. A trend towards damage of centriacinar pattern has been detected, which supports the theory that centriacinar emphysema results from local, direct damage to the respiratory bronchioles from exposure to cigarette smoke.

    • CYP1A1 polymorphism
    • emphysema
    • lung cancer
    • cigarette smoke

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.