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A non-isotopic method for the detection of telomerase activity in tumour tissues: TRAP-silver staining assay.
  1. J M Wen,
  2. L B Sun,
  3. M Zhang,
  4. M H Zheng
  1. Department of Pathology, Sun Yat-Sen University of Medical Sciences, Guangzhou, People's Republic of China.

    Abstract

    Telomerase activity has been observed in a high proportion of specimens from a wide variety of human malignant tumours, but not in non-neoplastic tissues. Measurement of telomerase activity is a possible diagnostic maker for malignant tumours. A non-isotopic telomeric repeat amplification protocol (TRAP) silver staining method for the detection of telomerase activity in human bone tumour tissues is described. The TRAP-silver staining method was quick, safe, and effective, and can be used as a routine diagnostic method for the detection of telomerase activity in bone tumours.

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