Article Text
Echoes
Gut reaction
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Specifically primed systemic T cells mediate colitis in mice. Splenic CD4+ CD45RBlow T cells are strongly implicated in colitis through production of tumour necrosis factor α (TNFα), according to results obtained in severe combined immunodeficient (SCID) mice.
SCID mice fed ovalbumin developed the hallmarks of colitis when reconstituted with …