A transcribed gene in an intron of the human factor VIII gene
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Cited by (163)
Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations
2017, American Journal of Obstetrics and GynecologyCitation Excerpt :This chemokine, which is induced by proinflammatory cytokines such as TNFα and IL-1β, recruits neutrophils and granulocytes to sites of inflammation.59 F8A1, which is nested within the largest intron of factor VIII, is transcribed in the opposite direction of the parent gene.60 Although its function is unknown, it is interesting to speculate about an involvement in coagulation.
Molecular Diagnostics for Coagulopathies
2016, Diagnostic Molecular Pathology: A Guide to Applied Molecular TestingAnimal models of hemophilia and related bleeding disorders
2013, Seminars in HematologyCitation Excerpt :An identical factor VIII transcript arising in different breeds, different places, and different decades suggests a common mutation mechanism. This involves repeated DNA elements like those that undergo spontaneous homologous recombination in humans.8–10 Dogs from the Queens University hemophilia A colony have a greater rate of forming inhibitor antibodies (“inhibitors”) to dog factor VIII when transfused to treat or prevent bleeding.11
Large-scale, Automated Sequencing of Human Chromosomal Regions
2012, Automated DNA Sequencing and AnalysisInfluence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: The ARIC Study
2012, BloodCitation Excerpt :FVIII introns vary from 0.2 kb for intron 17 to 32 kb for intron 22. Within intron 22, there are 2 distinct non-FVIII gene elements controlled by a bidirectional promoter.22,23 The FVIII mRNA is ∼ 9 kb that encodes a mature glycoprotein of 2332 aa without known alternatively spliced forms.2