Elsevier

Genomics

Volume 13, Issue 3, July 1992, Pages 862-865
Genomics

Sequence of the human factor VIII-associated gene is conserved in mouse

https://doi.org/10.1016/0888-7543(92)90170-WGet rights and content

Abstract

cDNA and genomic clones corresponding to the human factor VIII-associated gene (F8A) were isolated from mouse cDNA and F8A-enriched genomic libraries. The sequences of these clones revealed an intronless gene conding for 380 amino acids, with 85% identity the predicted human sequence. The single murine gene copy is genetically linked to factor VIII, but appears to lie outside the factor VIII gene by physical mapping. Like the human gene, the mouse F8A gene is highly expressed in a wide variety of tissues. This evolutionary comparison has helped to clarify the derived amino acid sequence in the human and strongly supports the hypothesis that the F8A gene encodes a protein.

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The mouse F8A sequence data have been deposited with GenBank under Accession No. M83118.

1

Present address: School of Medicine, University of California, San Diego, CA 92093.

2

Present address: Department of Medicine, University of Cambridge, Cambridge, CB2 2QQ UK.

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