Short communicationMidkine exists in astrocytes in the early stage of cerebral infarction
References (12)
- et al.
cDNA cloning and sequencing of a new gene intensely expressed in early differentiation of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis
Biochem. Biophys. Res. Commun.
(1988) - et al.
Brain injury in a dish: a model for reactive gliosis
Trends Neurosci.
(1994) - et al.
Midkine (MK), a retinoic acid-inducible growth/differentiation factor: immunochemical evidence for the function and distribution
Dev. Biol.
(1993) - et al.
Midkine that promotes survival of fetal human neurons is produced by fetal human astrocyte in culture
Dev. Brain Res.
(1993) - et al.
A retinoic acid-responsive gene, MK found in the teratocarcinoma system: heterogeneity of the transcript and the nature of the translation product
J. Biol. Chem.
(1990) - et al.
Midkine is present in the early stage of cerebral infarct
Dev. Brain Res.
(1995)
Cited by (25)
Midkine regulates amphetamine-induced astrocytosis in striatum but has no effects on amphetamine-induced striatal dopaminergic denervation and addictive effects: Functional differences between pleiotrophin and midkine
2011, NeuroscienceCitation Excerpt :Differences in the temporal regulation of PTN and MK in situations of brain damage could underlie the differential modulation of amphetamine-induced neurotoxicity by endogenous PTN and MK. Both PTN and MK are usually upregulated in astrocytes after nerve injury (Takeda et al., 1995; Wang et al., 1998; Mochizuki et al., 1998; Yeh et al., 1998; Kim et al., 2010). However, the temporal regulation of expression of both cytokines differs.
Midkine expression in rat spinal motor neurons following sciatic nerve injury
2004, Developmental Brain ResearchMidkine and pleiotrophin in neural development and cancer
2004, Cancer LettersMidkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
2002, Journal of Biological ChemistryAlteration of midkine expression in the ischemic brain of humans
2002, Journal of the Neurological SciencesIntraventricular administration of the neurotrophic factor midkine ameliorates hippocampal delayed neuronal death following transient forebrain ischemia in gerbils
2001, Brain ResearchCitation Excerpt :Gene knockout mice deficient in MK showed retarded postnatal development in the hippocampus [20]. Following experimental cerebral infarction in rats, MK expression is intensely induced in the surrounding edematic region, but not in the necrotic region, shortly after infarction [32,34]. Its expression is also increased in the hippocampal CA1 subfield following transient forebrain ischemia in rats [17].