Expression of genes of the IGF system in mononuclear cells from patients with acute lymphoblastic leukaemia (ALL) at diagnosis, healthy age matched controls, and cord blood samples
| Patients positive for expression (%) | |||||
|---|---|---|---|---|---|
| Controls | |||||
| Genes | ALL (N = 142) | Blood (N = 55) | Cord blood (N = 127) | ||
| Differences between the control group and the patients with ALL were tested with the κ2 test. | |||||
| *p≤0.05. | |||||
| IGF, insulin-like growth factor; IGFBP, IGF binding protein; IGFBP-rP, IGFBP related protein; IGF-IIR, IGF-II receptor; ND, not determined. | |||||
| IGF-I | 29% | 7% | 0.001* | 4% | 0.001* |
| IGF-II | 67% | 31% | 0.001* | 80% | 0.013* |
| IGF-IR | 68% | 87% | 0.010* | 39% | 0.001* |
| IGF-IIR | 60% | 63% | 0.726 | 76% | 0.050* |
| IGFBP-1 | 0% | ND | ND | ||
| IGFBP-2 | 63% | 60% | 0.660 | 5% | 0.001* |
| IGFBP-3 | 25% | 35% | 0.162 | 0% | 0.001* |
| IGFBP-4 | 42% | 44% | 0.860 | 24% | 0.002* |
| IGFBP-5 | 20% | 2% | 0.001* | 0% | 0.001* |
| IGFBP-rP1 | 17% | 7% | 0.089 | 13% | 0.456 |
| IGFBP-rP2 | 52% | 0% | 0.001* | 0% | 0.001* |