Expression of genes of the IGF system in mononuclear cells from patients with acute lymphoblastic leukaemia (ALL) at diagnosis
| ALL patients positive (%) | ||||
|---|---|---|---|---|
| Genes | Total (N = 142) | No relapse (N = 118) | Relapse (N = 24) | p Value |
| The group of 142 patients was divided into patients continuously in remission (no relapse, 118 patients) and those who relapsed (24 patients). | ||||
| Differences between the relapse and no relapse groups were tested with the κ2 test. | ||||
| *p≤0.05. | ||||
| IGF, insulin-like growth factor; IGFBP, IGF binding protein; IGFBP-rP, IGFBP related protein; IGF-IIR, IGF-II receptor. | ||||
| IGF-I | 29% | 29% | 29% | 0.972 |
| IGF-II | 67% | 65% | 75% | 0.355 |
| IGF-IR | 68% | 67% | 75% | 0.441 |
| IGF-IIR | 60% | 60% | 63% | 0.820 |
| IGFBP-1 | 0% | 0% | 0% | |
| IGFBP-2 | 63% | 59% | 83% | 0.026* |
| IGFBP-3 | 25% | 21% | 42% | 0.041* |
| IGFBP-4 | 42% | 40% | 54% | 0.195 |
| IGFBP-5 | 20% | 18% | 29% | 0.240 |
| IGFBP-rP1 | 17% | 16% | 24% | 0.405 |
| IGFBP-rP2 | 52% | 52% | 52% | 0.971 |