Group composition
| Group 1 |
| High grade prostatic intraepithelial neoplasia of the transition zone not associated with developing prostatic carcinoma (thus isolated). This lesion was present in 7 simple prostatectomy and in 3 cystoprostatectomy specimens from patients operated on because of benign prostatic hyperplasia and bladder cancer, respectively |
| Group 2 |
| High grade prostatic intraepithelial neoplasia of the transition zone associated with developing prostatic carcinoma. The foci were identified in 8 simple prostatectomy and 2 cystoprostatectomy specimens from patients with benign prostatic hyperplasia and bladder cancer, respectively |
| Group 3 |
| High grade prostatic intraepithelial neoplasia of the peripheral and central zones (in this study the central and peripheral zone are also referred to together as the outer prostate or “non-transition zone”) not associated with developing prostatic carcinoma. This group was composed of 10 patients who had urothelial cell carcinoma of the urinary bladder and had undergone cystoprostatectomy |
| Group 4 |
| High grade prostatic intraepithelial neoplasia of the non-transition zone associated with developing prostatic carcinoma. This group was composed of 10 patients with developing prostatic carcinoma diagnosed in a prostate biopsy. They underwent radical prostatectomy |
| Group 5 |
| High grade prostatic intraepithelial neoplasia simultaneously present in the non-transition and transition zones and not associated with developing prostatic carcinoma. This group was composed of 6 patients who underwent cystoprostatectomy as a result of bladder cancer |