Table 1

p53 mutations among 118 female patients with carcinoma of the rectum

PatientExon:codonMutationIHC (DO-7)
*Second carcinoma after radiotherapy of cervical cancer (see Methods).
ICH, immunohistochemical staining of formalin fixed, paraffin wax embedded section of the tumours with DO-7 anti-p53 antibody; –, < 20% positive nuclei; +, ≥ 20% positive nuclei; NT, not tested.
RE1104:100CAG → CGGGln → Arg+
RE524:110CGT → TGTArg → Cys+
RE61*4:110CGT → TGTArg → Cys+
RE664:110CGT → TGTArg → Cys+
RE119*4:110CGT → TGTArg → Cys–
RE1165:140–144Deletion 14 bp (CCTGCCCTGTGCAG)NT
RE45:151CCC→TCCCCC → TCC+
RE425:167CAG → TAGGln → STOP–
RE585:175CGC → CACArg → His+
RE129*5:175CGC → CACArg → His+
RE41*5:176TGC → TGACys → STOP-
RE127*5:176Deletion 2 bp (GC)-
RE37*5:179CAT → CGTHis → Arg+
RE385:181CGC → CCCArg → Pro+
RE69*6:188–196Deletion 28 bp (CGGATAAGATGCTGAGGAGGGGCCAGAC)+
RE126:214–215Deletion 2 bp (TA)–
RE866:216GTG → TTGVal → Leu+
RE73*7:232ATC → AACIle → Asn+
RE727:235Insertion 9 bp (TTCCTTACA)+
RE367:236TAC → AACTyr → Asn+
RE65*7:245GGC → AGCGly → Ser+
RE67*7:245GGC → AGCGly → Ser+
RE767:245GGC → AGCGly → SerNT
RE1047:245GGC → AGCGly → Ser+
RE67:248CGG → CAGArg → Gln+
RE447:248CGG → TGGArg → Trp+
RE827:248CGG → TGGArg → Trp+
RE103*7:250Deletion 2 bp (CC)–
RE747:254ATC → AACIle → Asn+
RE288:263–265Insertion 9 bp (AATCTACTG)+
RE568:270TTT → CTTPhe → Leu+
RE28:273CGT → AGTArg → Ser+
RE49*8:273CGT → CATArg → HisNT
RE57*8:273CGT → CATArg → His+
RE99*8:273CGT → TGTArg → Cys+
RE1348:273CGT → TGTArg → Cys+
RE1308:273Duplication 25 bp (GTGTTTGTGCCTGTCCTGGGAGAGA)–
RE648:277TGT → TTTCys → Phe+
RE7*8:282CGG → TGGArg → Trp+
RE248:282CGG → TGGArg → Trp+
RE1128:306CGA → TGAArg → STOP–