Ultrastructural localisation of complement components and regulatory proteins on the cell membrane of gastric cells
| Localisation on gastric cells | |||
|---|---|---|---|
| Complement components and regulatory proteins | Basal membrane | Lateral membrane | Luminal membrane |
| DAF, decay accelerating factor; MCP, membrane cofactor protein; −, negative; ±; occasionally positive; +, weakly positive; ++, strongly positive. | |||
| Uninvolved mucosa (n=3) | |||
| C3d | ++ | − | − |
| C5b–9 | + | − | − |
| MCP (CD46) | ++ | ++ | − |
| DAF (CD55) | − | − | + |
| S protein | ++ | − | − |
| Protectin (CD59) | + | − | + |
| Differentiated adenocarcinoma (n=3) | |||
| C3d | ++ | − | + |
| C5b–9 | + | − | ± |
| MCP (CD46) | ++ | ++ | − |
| DAF (CD55) | − | + | ++ |
| S protein | ++ | − | ± |
| Protectin (CD59) | ++ | + | ++ |
| Undifferentiated adenocarcinoma (n=1) | |||
| C3d | − | ||
| C5b–9 | − | ||
| MCP (CD46) | ++ (circumferential cell membrane staining) | ||
| DAF (CD55) | ++ (circumferential and/or luminal cell membrane staining) | ||
| S protein | − | ||
| Protectin (CD59) | − | ||