Table 1

Canonical structure classification of the hypervariable loop regions of monoclonal antibody 2G10 ² V _L and V _H according to Clothia and co-workers, ³⁷ showing sequence similarities with known antibody structures (McP603, ⁴² HyHeL45, ⁴⁰ and NC41 ⁴¹ )

	Canonical structure	CDR residues																			FRW residues
Apart from the L1 region, the Kabat¹³ and Clothia³⁷ systems agree in terms of amino acid numbering of the hypervariable loop regions.
Numbers in bold represent residue positions according to the Kabat system.¹³
*Canonical determinants.
FRW, framework region.
		25	26	27	a	b	c	d	e	f	28	29	30	31	32	33					2	71
L1 region		25*	26	27	28	29*	30	31	a	b	c	d	e	f	32	33*					2*	71*
2G10		A	S	E	S	V	E	Y	–	–	F	G	T	G	L	M					I	F
McP603	3	S	S	E	S	L	L	N	S	G	N	E	K	N	F	L					I	F

L2 region		50	51	52																	48*	64*
2G10		T	A	S																	I	G
McP603	1	G	A	S																	I	G

L3 region		90*	91	92	93	94	95*	96*
2G10		Q	S	R	K	V	P	S
McP603	1	N	D	H	S	Y	P	L

H1 region		31	32	34*													26*	27*	28	29*	30	94*
2G10		S	H	M													G	Y	T	F	T	K
McP603	1	S	Y	M													G	F	I	F	S	R

H2 region		52a	b	c	53	54	55*															71*
2G10		P	–	–	Y	N	D															S
HyHeL5	2	P	–	–	G	S	G															A
NC41		T	–	–	N	T	G															L