Table 2

TRANSFAC analysis identified several potential transcription factor binding sites in the 600 bp fragment (−559 to +39) of the ccn2 (ctgf) promoter

Position	Transcription factor binding site	Core similarity (%)	Matrix similarity (%)
Default settings of the Matinspector professional software were used (core similarity, 0.85; matrix similarity, 0.75). Only potential transcription factor binding sites with a core similarity of 1 are shown.
*Matrix similarity in MZF1 in the GG genotype.
†GC genotype.
‡Pbx-1 matrix similarity in CC genotype.
¶In GC genotype.
−524 to −521	MBP-1/RFX1 complex	100	75.3
−473 to −470	TATA box	100	85.1
−467 to −462	Oct1	100	86.0
−467 to −462	GFI1	100	97.1
−444 to −441	MZF1	100	98.6*, 98.02†
−418 to −415	Ikaros 3	100	89.4
−418 to −415	STAT 1	100	89.2
−384 to −381	STAT 1	100	89.2
−319 to −316	S8	100	96.2
−319 to −316	Homeo domain factor Nkx-2.5/Cxs, tinman	100	88.2
−307 to −304	HNF-3/homolog 8	100	95.4
−307 to −303	FREAC 4	100	79.3
−306 to −303	HNF-3/homolog 1	100	85.3
−304 to −301	TATA box	100	91.9
−301 to −299	FREAC 2	100	89.1
−288 to −285	NF-E2 p45	100	86.9
−248 to −245	E2F	100	84.9
−219 to −216	NFAT	100	98.3
−174 to −167	SMAD binding element	100	Ref 21
−156 to −144	TGFβ responsive element	100	Ref 20
−152 to −149	ARP1	100	89.4
−145 to −142	MEF3	100	83.4
−141 to −138	Cut-like homeo domain protein	100	97.5
−138 to −135	Pbx-1	100	82.1‡, 81.8¶
−106 to −103	MZF1	100	99.5
−92 to −89	c-Rel	100	96.1
−92 to −89	NFκB p65	100	89.7
−86 to −82	NFκB	100	92.5
−82 to −79	HNF-3/homolog 8	100	90.5
−56 to −52	CCAAT box	100	91.5
−55 to −41	Nuclear factor Y box	100	94.9
−29 to −23	TATA box	100	99.0
−10 to −7	SP-1	100	91.4
−10 to –7	RRE	100	86.2
−8 to –5	E2F	100	84.9
15 to 18	GABP	100	88.7
15 to 18	Elk-1	100	91.7
15 to 18	NRF-2	100	95.6