Details of p53 mRNA alterations
| Patient | Disease | Exon | Codon | Mutation | Amino acid | Note |
|---|---|---|---|---|---|---|
| A-CLL, atypical B cell chronic lymphocytic leukaemia; AS, alternative splice products; M, mantle cell lymphoma; T-CLL, typical B cell chronic lymphocytic leukaemia; UN, low grade unclassified non-Hodgkin's lymphoma. | ||||||
| 1 | T-CLL | 7 | 248 | CGG/GGG | arg/gly | Hemizygous |
| 2 | T-CLL | 5 | 135 | TGC/TTC | cys/phe | Hemizygous |
| 3 | A-CLL | AS | Multiple aberrant splice products | |||
| 4 | UN | 5 | 163 | TAC/TGC | try/cys | Heterozygous |
| 5 | A-CLL | 6 | 213 | CGA/CGG | arg/arg | Polymorphism/heterozygous |
| 6 | M | 8 | 270 | TTT/CTT | phe/leu | |
| 7 | A-CLL | AS | Alternative splice product | |||
| 8 | A-CLL | 8 | 266 | GGA/CGA | gly/arg | Hemizygous |
| 9 | T-CLL | Small clone, not sequenced | ||||