Table 1

Genes of the sequenced γ-herpesviruses^2,^7,^23–²⁶ ^28–³⁰

Gene block	EBV	HVS	EHV-2	HHV-8	MHV-68	AHV-1	RRV	HVA	Comments
Homologous genes are generally listed in the same rows; non-homologous genes listed in the same rows are italicised. Homologous and/or functionally analogous genes within the divergent loci (γDL-A to γDL-D) are indicated in bold type; the multiple IRF genes in HHV-8 and RRV are homologous, but “closest neighbours” are difficult to define.
Some HHV-8 IRF ORF numbers differ from those published previously (24, 25); ORFs K9, K10.1, K10.2, and K11.1 in this table correspond to vIRF genes 1, 4, 3, and 2, respectively.
AHV-1, alcelaphine herpesvirus 1; BCK, β-chemokine; BHV-4, bovine herpesvirus 4; bZIP, basic leucine zipper; EBERs, Epstein-Barr virus early RNAs; EBNA, Epstein-Barr virus encoded nuclear antigen; EBV, Epstein-Barr virus; EHV-2, equine herpesvirus 2; FGARAT, N-formylgycinamide ribotide amidotransferase; FLIP; FLICE inhibitory protein; GCR, G protein coupled receptor; HHV-8, human herpesvirus 8; HVA, herpesvirus ateles; HVS, herpesvirus saimiri; IE, immediate–early genes; LMP, latency membrane protien; MHV-68, murine herpesvirus 68; MIP-1, macrophage inflammatory protein 1; ORF, open reading frame; Pol., polymerase; RRV, rhesus rhadinovirus; STP, saimiri transformation associated protein; tip, tyrosine kinase interacting protein.
γDL-A	BNLF1 (LMP-1)	1 (STP)		K1			R1	1 (STP/tip)	Transforming membrane proteins
	BNLF2
		[uRNAs]	E1 (GCR)						E1 chemokine receptor
		2 (DHFR)	E2				2 (DHFR)		Dihydrofolate reductase
		[uRNAs]	E3		[tRNAs]			[uRNAs]	Pol. III transcripts (u/t RNAs)
		3 (FGARAT)	3 (FGARAT)					3 (FGARAT)	Virion protein, FGARAT
	BARF1		E4		M1 (serpin)	A1			M1, immune regulator?
	BALF1								Bcl-2 homologue
					M2	A2			M2, latent expression
					[tRNAs]	A3 (semaphorin)			A3, chemoattractant
					M3	A4
					M4	3 (FGARAT)
		4 (CCP)		4 (CCP)	4 (CCP)		4 (CCP)	4 (CCP)	Complement control protein
		5
I	BALF2	6	6	6	6	6	6	6	ssDNA binding protein
	BALF3	7	7	7	7	7	7	7	Transport protein
	BALF4	8	8	8	8	8	8	8	Glycoprotein B
	BALF5	9	9	9	9	9	9	9	DNA polymerase
			E5
			E6			A5			Probable GCRs
	LF1	10	10	10	10	10	10	10
	LF2	11	11	11	11	11	11	11
γDL-B	LF3
	BILF1								Probable GCR
				K2 (IL-6)			R2 (IL-6)		Interleukin 6
				2 (DHFR)					Dihydrofolate reductase
		12		K3 (IE1B)	K3				BHV-4 IE1 homologues
				70 (TS)			70 (TS)		Thymidylate synthase
				K4 (MIP-1)			R3 (MIP-1)		Chemokine homologues
				K4.5 (BCK)					Chemokine homologue
				K5 (IE1A)					BHV-4 IE1 homologue
				K6 (MIP-1)					Chemokine homologue
		13							Interleukin 17
		14 (IE-G)						14	IE/superantigen (HVS)
	BILF2		12	K7	M5
		15	13		M6				15, CD59 homologue
		16 (bcl-2)		16 (bcl-2)			16 (bcl-2)	16 (bcl-2)	Bcl-2 homologues
II	BVRF2	17	17	17	17	17	17	17	Assembly protein
	BVLF1.5	18	18	18	18	18	18	18
	BVRF1	19	19	19	19	19	19	19	Tegument protein
	BXRF1	20	20	20	20	20	20	20	Fusion protein
	BXLF1	21	21	21	21	21	21	21	Thymidine kinase
	BXLF2	22	22	22	22	22	22	22	Glycoprotein H
	BTRF1	23	23	23	23	23	23	23
	BcRF1	24	24	24	24	24	24	24
	BcLF1	25	25	25	25	25	25	25	Major capsid protein
	BDLF1	26	26	26	26	26	26	26	Capsid protein
	BDLF2	27	27	27	27	27	27	27
	BDLF3	28	28	28			28	28
III	BDRF1	29b	29b	29b	29b	29b	29b	29b	DNA packaging protein
		30	30	30	30	30	30	30
	BDLF4	31	31	31	31	31	31	31
	BGLF1	32	32	32	32	32	32	32
	BGLF2	33	33	33	33	33	33	33
	BGRF1	29a	29a	29a	29a	29a	29a	29a	DNA packaging protein
	BGLF3	34	34	34	34	34	34	34
		35	35	35	35	35	35	35
	BGLF4	36	36	36	36	36	36	36	Phosphotransferase
	BGLF5	37	37	37	37	37	37	37	Alkaline exonuclease
	BBLF1	38	38	38	38	38	38	38	Tegument protein
	BBRF3	39	39	39	39	39	39	39	Glycoprotein M
	BBLF2	40	40	40	40	40	40	40	Helicase–primase complex
	BBLF3	41	41	41		41	41	41	Helicase–primase complex
	BBRF2	42	42	42	42	42	42	42
	BBRF1	43	43	43	43	43	43	43	Minor capsid protein
	BBLF4	44	44	44	44	44	44	44	Helicase
	BKRF4	45	45	45	45	45	45	45
	BKRF3	46	46	46	46	46	46	46	Uracil DNA glycosylase
	BKRF2	47	47	47	47	47	47	47	Glycoprotein L
	BKRF1
	BRRF2
	BRRF1	48	48	48	48	48	48	48
		49	49	49	49		49	49
	BRLF1	50	50	50	50	50	50	50	R transactivator (Rta), IE
γDL-C	BZLF1			K8					bZIP protein
						A6
						A7
		51	51	K8.1	M7	A8		51	Glycoprotein
	BZLF2
	BERF3/4								EBNA3C
	BERF2a/b								EBNA3B
	BL/ERF3/1
	BLLF1a/b
	BLLF2
IV`	BLRF2	52	52	52	52	52	52	52
	BLRF1	53	53	53	53	53	53	53
	BLLF3	54	54	54	54	54	54	54	dUTPase
	BSRF1	55	55	55	55	55	55	55
	BSLF1	56	56	56	56	56	56	56	Primase
	BSLF2				M8
	BMLF1 (Mta)	57 (IE-52K)	57	57	57	57	57	57	Immediate–early, postranscriptional reg.
IRF				K9 (IRF)			R6 (IRF)		Interferon regulatory factor
				K10			R7 (IRF)		Interferon regulatory factor (R7)
				K10.1 (IRF)			R8 (IRF)		Interferon regulatory factor
				K10.2 (IRF)			R9 (IRF)		Interferon regulatory factor
				K11 (gX)			R10 (IRF)		Interferon regulatory factor (R10)
				K11.1(IRF)			R11 (IRF)		Interferon regulatory factor
							R12 (IRF)		Interferon regulatory factor
							R13 (IRF)		Interferon regulatory factor
IV`	BMRF2	58	58	58	58	58	58	58
	BMRF1	59	59	59	59	59	59	59	Processivity factor
	BaRF1	60	60	60	60	60	60	60	RR (small subunit)
	BORF2	61	61	61	61	61	61	61	RR (large subunit)
	BORF1	62	62	62	62	62	62	62	Capsid assembly protein
	BOLF1	63	63	63	63	63	63	63	Tegument protein
	BPLF1	64	64	64	64	64	64	64	Large tegument protein
	BFRF3	65	65	65	M9	65	65	65	Capsid protein
	BFRF2	66	66	66	66	66	66	66
	BFRF1	67	67	67	67	67	67	67	Tegument protein
	BFRF0.5	67A	67A	67A		67A		67A
			E7						Interleukin 10
	BFLF1	68	68	68	68	68	68	68	Envelope glycoprotein?
	BFLF2	69	69	69	69	69	69	69
γDL-D	BHRF1								Bcl-2 homologue
	BHLF1				M10a/b/c				Repeat region
	BYRF1								EBNA2
	BWRF1								Repeats, EBNA2-LP
	BCRF1								Interleukin 10 homology
	[EBERs]								Pol. III transcripts
				K12					Kaposin, latent
		70 (TS)	70 (TS)					70 (TS)	Thymidylate synthase
		71(FLIP)		71 (FLIP)			71 (FLIP)	71 (FLIP)	FLICE inhibitory prot.
		72 (cyclin)		72 (cyclin)	72 (cyclin)		72 (cyclin)	72 (cyclin)	Cyclin-D homologue
		73	73	73 (LNA)	73	73	73	73	Latency nuclear antigen (HHV-8)
				K14 (Ox-2)			R15 (Ox-2)		N-CAM homologue
					M11				Functional bcl-2 homolgue
		74 (GCR)	74 (GCR)	74 (GCR)	74 (GCR)		74 (GCR)	74 (GCR)	Interleukin 8 receptor homologue
			E8						FLICE inhibitory protein
	BNRF1	75	75	75	75c	75	75	75	Virion protein, FGARAT
					75b				Virion protein, FGARAT
					75a				Virion protein, FGARAT
	LMP-2			K15					Functional equivalence?
									(Also with HVS-C Tip?)
			E9		M12	A9
			E10		M13	A10			A10, Bcl-2 homologue
			E1		M14