Viral gene expression in Epstein-Barr virus (EBV) associated tumours
| Tumour | Latent gene expression | Pattern of latency |
|---|---|---|
| Note that all EBV positive tumours express the EBER RNAs and the BamHIA transcripts. Preliminary work suggests that another form of latency exists with expression of EBNA1 and LMP2 only, and this is often seen in NPC and gastric adenocarcinomas. | ||
| BL, Burkitt's lymphoma; EBNA, EBV encoded nuclear antigen; LMP, latent membrane protein; NPC, nasopharangeal carcinoma. | ||
| BL, endemic | EBNA1 | I |
| BL, sporadic/AIDS | EBNA1 | I |
| Undifferentiated NPC | EBNA1; LMPs 1, 2 | II |
| Hodgkin's disease | EBNA1; LMPs 1, 2 | II |
| T lymphomas | EBNA1; LMPs 1, 2 | II |
| Immunoblastic lymphomas | EBNAs 1–6; | III |
| LMPs 1, 2 | III | |