Distribution of Rsa I, Dra I, and Taq I genotypes and less common allele frequencies among patients with alcoholic liver disease (ALD), patients with hepatocellular carcinoma (HCC), and healthy controls
| Number of individuals (% of group) | ||||||
|---|---|---|---|---|---|---|
| Homozygous more common allele | Heterozygous | Homozygous less common allele | Less common allele frequency | χ2 value (p value) | Odds ratio (95% CI) | |
| Statistical calculations are based on comparisons of allele frequency. | ||||||
| †p Value using the two tailed Fisher's exact test. | ||||||
| CI, confidence interval. | ||||||
| Rsa I polymorphism | c1c1 | c1c2 | c2c2 | |||
| Controls (n = 375) | 350 (93%) | 25 (7%) | 0 (0%) | 0.033 | – | 1.0 |
| ALD (n = 61) | 59 (97%) | 2 (3%) | 0 (0%) | 0.016 | (0.41)† | 0.48 (0.05 to 1.98) |
| HCC (n = 28) | 27 (96%) | 1 (4%) | 0 (0%) | 0.018 | (≈ 1.00)† | 0.53 (0.01 to 3.35) |
| Dra I polymorphism | DD | DC | CC | |||
| Controls (n = 375) | 305 (81%) | 68 (18%) | 2 (<1%) | 0.096 | – | 1.0 |
| ALD (n = 61) | 50 (82%) | 11 (18%) | 0 (0%) | 0.090 | < 0.01 (0.97) | 0.93 (0.43 to 1.84) |
| HCC (n = 31) | 24 (77%) | 6 (20%) | 1 (3%) | 0.129 | 0.38 (0.54) | 1.40 (0.55 to 3.10) |
| Taq I polymorphism | A2A2 | A2A1 | A1A1 | |||
| Controls (n = 375) | 279 (75%) | 91 (24%) | 5 (1%) | 0.135 | – | 1.0 |
| ALD (n = 61) | 55 (90%) | 6 (10%) | 0 (0%) | 0.049 | 6.35 (0.01) | 0.33 (0.12 to 0.78) |
| HCC (n = 44) | 36 (82%) | 7 (16%) | 1 (2%) | 0.102 | 0.47 (0.49) | 0.73 (0.31 to 1.52) |