Summary of the meta-analysis, using the “random effects model”, of the current and previous studies of whether possession of the c2 allele is related to the risk of developing alcoholic liver disease (ALD)
| Reference | ALD/ cirrhosis* | Healthy controls* | Weight (%) | Odds ratio (95% CI) |
|---|---|---|---|---|
| *Number of c2 alleles/total number of alleles. | ||||
| CI, confidence interval. | ||||
| Parsian et al (1998)12 | 0/86 | 2/178 | 3.4 | 0.41 (0.02 to 8.59) |
| Wong et al (current study) | 2/122 | 25/750 | 10.9 | 0.48 (0.05 to 1.98) |
| Ingelman-Sundberg et al (1993)3 | 3/112 | 10/228 | 12.3 | 0.60 (0.16 to 2.22) |
| Agúndez et al (1996)10 | 2/116 | 7/274 | 9.6 | 0.67 (0.14, 3.27) |
| Ball et al (1995)7 | 3/74 | 6/216 | 11.2 | 1.48 (0.36 to 6.07) |
| Lucas et al (1996)9 | 9/220 | 13/520 | 18.7 | 1.66 (0.70 to 3.95) |
| Grove et al (1998)13 | 14/480 | 4/242 | 14.7 | 1.79 (0.58 to 5.49) |
| Carr et al (1995)6 | 5/106 | 1/64 | 6.0 | 3.12 (0.36 to 27.3) |
| Pirmohamed et al (1995)8 | 19/190 | 3/200 | 13.2 | 7.30 (2.12 to 25.1) |
| Total | 57/1506 | 71/2672 | 100.0 | 1.41 (0.78 to 2.55) |