Table 3

Summary of the findings of previous studies on the association between CYP2E1 genetic polymorphisms and susceptibility to alcoholic liver disease (ALD) in white populations

Reference	Population studied	Study group (n)	c2 allele frequency	p Value	C allele frequency	p Value
*Chi squared test with Yates correction; §two tailed Fisher's exact test; #healthy controls; ¶alcohol related cirrhosis; †no raw data given.
Ingelman-Sundberg et al (1993)³	Italian	Control# (114)	0.044	0.56§	0.083	0.22*
		Cirrhosis¶ (56)	0.027		0.036
Carr et al (1995)⁶	North American	Control# (32)	0.016	0.41§	–	–
		ALD (53)	0.047
Ball et al (1995)⁷	British	Control# (114)	0.028	0.70§	–	–
		Cirrhosis¶ (37)	0.041
Pirmohamed et al (1995)⁸	British	Control# (100)	0.015	0.0006*	–	–
		ALD (95)	0.100
Lucas et al (1996)⁹	French	Control# (260)	0.025	0.35*	0.079	0.008*
		Cirrhosis¶ (110)	0.041		0.146
Agúndez et al (1996)¹⁰	Spanish	Control# (137)	0.026	≈ 1.00§	–	–
		Cirrhosis¶ (58)	0.017
Savolainen (1997)¹¹	Finnish	No ALD (33)	†	–	0.045	0.08*
		ALD (207)	0.010		0.130
Parsian et al (1998)¹²	North American	Control# (89)	0.011	≈ 1.00§	0.107	0.90*
		Cirrhosis¶ (43)	0.000		0.093
Grove et al (1998)¹³	British	Control# (121)	0.017	0.44*	–	–
		ALD (240)	0.029		–
Wong et al (current study)	British	Control# (375)	0.033	0.41§	0.096	0.97*
		ALD (61)	0.016		0.090