Comparison of gene amplification in tumours from patients with BRCA1 mutations and patients with breast cancer unselected for family history stratified by age
| Marker | Age (years) | BRCA1 mutation cases | Non-familial controls | p Values |
|---|---|---|---|---|
| HER2 amplification data were captured only for samples that were previously identified as overexpressing HER2 protein. | ||||
| p Values were determined using the two tailed Fisher's exact test. | ||||
| ND, not determined. | ||||
| CCND1 | <50 | 0/20 | 17/48 | 0.002 |
| ≥50 | 0/10 | 2/26 | 1.0 | |
| HER2 | <50 | 0/2 | 13/17 | 0.09 |
| ≥50 | 1/1 | 0/0 | ND | |