Allele frequencies for four factor VIII gene polymorphisms frequently used in linkage studies in haemophilia A
| Frequency | ||||||
|---|---|---|---|---|---|---|
| Location | Name | Alleles | Whites | Japanese | Chinese | American blacks |
| Source references, white: Bcl1,59 HindII,59 Xbal A,42 Bgl1,45; all Japanese data60; Chinese: Bcl1,61 HindIII,59 Xba1,61; American black: Bcl1,59 HindII,59 and Bgl1.45 | ||||||
| Intron 18 | BclI | + | 0.76 | 0.70 | 0.82 | 0.20 |
| – | 0.24 | 0.30 | 0.18 | 0.80 | ||
| Intron 19 | HindIII | + | 0.25 | 0.24 | 0.78 | |
| – | 0.75 | 0.76 | 0.22 | |||
| Intron 22 | XbaI A | + | 0.58 | 0.59 | 0.57 | |
| – | 0.42 | 0.41 | 0.43 | |||
| Intron 25 | BglI | + | 0.90 | 0.91 | 1 | 0.74 |
| – | 0.10 | 0.09 | 0 | 0.26 | ||