Biochemical and Biophysical Research Communications
Regular ArticleTranslocation of Retinoblastoma Protein Associated with Tumor Cell Growth Inhibition
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Cell cycle-controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation
2006, Journal of Biological ChemistryCitation Excerpt :Hence, it is tempting to suggest that the targeting of Rb by the E7 oncoprotein contributes to cancer formation via deregulation of nucleolin, which in turn leads to an activation of HPV18 oncogene expression, in HPV18-associated cervical carcinogenesis. In line with several previous reports, revealing that Rb can accumulate in the nucleolus (59-62), our results obtained with CV1 and BT549-Rb cells (Fig. 3H) (data not shown), suggest that Rb and nucleolin localize together in G1 phase. Of note, Rb immunostaining patterns can be variable (63), and, even in living cells, accumulation of Rb in the nucleolus is cell type-dependent (62).
Binding of pRB to the PHD protein RBP2 promotes cellular differentiation
2005, Molecular CellCitation Excerpt :Under low serum conditions, which favor the accumulation of hypophosphorylated or “active” pRB and promote cell-cycle exit, pRB concentrated in nucleoli in either a “pannucleolar” or “nucleolar rim” pattern. Nucleolar accumulation of hypophosphorylated pRB has been reported by others (Angus et al., 2003; Cavanaugh et al., 1995; Hannan et al., 2000; Kennedy et al., 2000; Rogalsky et al., 1993). Next, SAOS-2 RB−/− human osteosarcoma cells were transfected to produce pRB wild-type (WT), Δ663, or Δex22.
Strategies for Approaching Retinoblastoma Tumor Suppressor Gene Therapy
1997, Advances in PharmacologyThe novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus
2010, Nucleic Acids ResearchFinding Plk3
2007, Cell Cycle