Regular Article
Progesterone Rapidly Decreases Brain Edema: Treatment Delayed up to 24 Hours Is Still Effective

https://doi.org/10.1006/exnr.1996.0063Get rights and content

Abstract

Cerebral edema is a serious side effect of traumatic brain injury. We have previously established that progesterone injections, initiated within 1 h after cortical contusion injury, reduced edema when assessed 3 days later. To determine how rapidly progesterone can reduce edema, male and female rats were given the hormone 1 h after damage to the medial frontal cortex, and edema levels were assessed between 2 h and 7 days postinjury. Progesterone decreased edema within 6 h of the injury and continued to be effective for the duration of treatment. In addition, we assessed whether progesterone injections are effective when delays are imposed between injury and initiation of treatment. Male and female rats received progesterone after postinjury delays of 6, 24, or 48 h. Progesterone was effective in reducing edema when treatment was delayed until 24 h after injury.

References (0)

Cited by (230)

  • Antioxidant therapies in traumatic brain injury

    2022, Neurochemistry International
  • Traumatic Brain Injury

    2020, Braddom's Physical Medicine and Rehabilitation
View all citing articles on Scopus
1

To whom correspondence should be addressed at Department of Psychology, Texas Christian University, Fort Worth, TX 76129. Fax: (817) 921-7110.

View full text