Elsevier

Gynecologic Oncology

Volume 71, Issue 2, November 1998, Pages 172-176
Gynecologic Oncology

Regular Article
Cytogenetics of Uterine Sarcomas: Presentation of Eight New Cases and Review of the Literature

https://doi.org/10.1006/gyno.1998.5165Get rights and content

Abstract

Tissue from 14 uterine tumor samples from eight patients—four with endometrial stromal sarcoma (ESS), two with leiomyosarcoma (ULMS), and two with malignant mixed mesodermal tumor (MMMT)—were investigated cytogenetically after short-term culturing. Clonal chromosome aberrations were found in 12 tumors. One ESS showed a recombination between 7p14 and 17q12, a rearrangement characterizing a subset of ESSs. In our series, chromosomes 1, 6, 7, and 16 were involved in structural aberrations most frequently (four cases each). Net loss of 6q material was found in four cases and bands 11q13, 16q13, and 22q13 were each rearranged in four cases. Among 43 uterine sarcomas, including 12 MMTs, now available for evaluation, some differences in breakpoint distribution among different tumor types were found. Rearrangements of bands 1p32, 3p24, and 10q22 were found exclusively in ULMS, whereas aberrations of bands 6p21, 7p21, and 17q12 were found predominantly in ESS.

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This work was supported by Grant 4.PO5A.079.10 from the Polish State Committee for Scientific Research, the Swedish Cancer Society, and the Coleman Leukemia Research Fund.

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To whom correspondence and reprint requests should be addressed at Department of Biology and Genetics, Medical University of Gdańsk, 1 Dębinki St., 80-211 Gdańsk, Poland. Fax:48–58–302–32–76. E-mail:[email protected].

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