Regular ArticleSingle-Molecule Imaging of Human Insulin Receptor Ectodomain and Its Fab Complexes☆,☆☆
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2023, Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric DisordersStructural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors
2015, StructureCitation Excerpt :In the case of the IR homodimer, these domains arrange in a two-fold symmetric, disulfide-linked Λ-shaped conformation (McKern et al., 2006; Smith et al., 2010; Tulloch et al., 1999) (Figure 1A). The ectodomain of IGF-1R likely exhibits a similar conformation (Tulloch et al., 1999; Whitten et al., 2009). Of fundamental importance to ligand binding is the C-terminal region (αCT) of the receptor α chain (Kurose et al., 1994), which in the case of IR has been shown to assemble in a predominantly α-helical conformation on the central β-sheet (L1-β2) of the L1 domain of the opposite monomer (Smith et al., 2010).
The insulin receptor: a prototype for dimeric, allosteric membrane receptors?
2008, Trends in Biochemical Sciences
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Peter Tulloch passed away on June 14, 1998.
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Coligan, J. E.Kruisbeek, A. M.Margulies, D. H.Shevach, E. M.Strober, W.
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