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The mycobacterial 65 kD heat-shock protein and autoimmune arthritis

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Summary

Arthritis — induced experimentally in rats by immunization with mycobacteria has been shown to depend on specific T cell recognition of an epitope present on the mycobacterial 65-kD heat-shock protein. This particular epitope has been observed to have a structural mimicry with a cartilage-associated molecule present in the joints. Since the bacterial heat-shock proteins and the cartilage-associated molecules are of a conserved nature, one might infer from the experimental model that in humans similar mimicry could play a role in the initiation of autoimmune arthritis. Recent findings from the analysis of immunological reactivity to the 65-kD in rheumatoid arthritis patients seem to support such a role for the mycobacterial 65-kD heat-shock protein in human disease.

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References

  1. Pearson CM (1956) Development of arthritis, periarthritis and periostitis in rats given adjuvant. Proc Soc Exp Biol Med 91:95–101

    Google Scholar 

  2. Pearson CM, Wood FD (1964) Passive transfer of adjuvant arthritis by lymph node or spleen cells. J Exp Med 120:547–560

    Google Scholar 

  3. Batisto JR, Smith RN, Bechman K, Sternlight M, Welles WL (1982) Susceptibility to adjuvant arthritis in DA and F344 rats. A dominant trait controlled by an autosomal gene locus linked to the major histocompatibility complex. Arthritis Rheum 25:1194–1200

    Google Scholar 

  4. Cohen IR, Holoshitz J, Van Eden W, Frenkel A (1985) Lines of T lymphocytes illuminate pathogenesis and affect therapy of experimental arthritis. Arthritis Rheum 28:841–845

    Google Scholar 

  5. Holoshitz J, Naparstek Y, Ben-Nun A, Cohen IR (1983) Lines of T lymphocytes induce or vaccinate against autoimmune arthritis. Science 219:56–58

    Google Scholar 

  6. Holoshitz J, Matitiau A, Cohen IR (1984) Arthritis induced in rats by clones of T lymphocytes responsive to mycobacteria but not to collagen type II. J Clin Invest 73:211–215

    Google Scholar 

  7. Cohen IR (1986) Regulation of autoimmune disease: physiological and therapeutic. Immunol Rev 94:5–21

    Google Scholar 

  8. Van Eden W, Holoshitz J, Nevo Z, Frenkel A, Klajman A, Cohen IR (1985) Arthritis induced by a T lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans. Proc Natl Acad Sci USA 82:5064–5067

    Google Scholar 

  9. Van Eden W, Holoshitz J, Cohen IR (1987) Antigenic mimicry between mycobacteria and cartilage proteoglycans: the model of adjuvant arthritis. Concepts Immunopathol 4:144–170

    Google Scholar 

  10. Van Vollenhoven RF, Soriano A, McCarthy PE, Schwartz RL, Garbrecht FC, Thorbecke GJ, Siskind GW (1988) The role of immunity to cartilage proteoglycan in adjuvant arthritis. J Immunol 141:1168–1173

    Google Scholar 

  11. Van den Broek MF, Van den Berg WB, Arntz OJ, Van de Putte LBA (1988) Reaction of bacterium-primed murine T cells to cartilage components: a clue for the pathogenesis of arthritis? Clin Exp Immunol 72:9–14

    Google Scholar 

  12. Van Eden W, Thole JER, Van der Zee R, Noordzij A, Van Embden JDA, Hensen EJ, Cohen IR (1988) Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 331:171–173

    Google Scholar 

  13. Thole JER, Hindersson P, De Bruyn J, Cremers F, Van der Zee J, De Cock H, Tommassen J, Van Eden W, Van Embden JDA (1988) Antigenic relatedness of a strongly immunogenic 65 kD mycobacterial protein antigen with a similarly sized ubiquitous bacterial common antigen. Microb Pathog 4:71–83

    Google Scholar 

  14. Young DB, Ivanyi J, Cox JH, Lamb JR (1987) The 65 kDa antigen of mycobacteria — a common bacterial protein? Immunol Today 8:215–219

    Google Scholar 

  15. Fox R, Sportsman R, Rhodes G, Luka J, Pearson G, Vaughan J (1986) Rheumatoid arthritis synovial membrane contains a 62 000 MW protein that shares an antigenic epitope with the Epstein-Barr virus encoded associated nuclear antigen. J Clin Invest 77:1539–1547

    Google Scholar 

  16. Kubo T, Towle CA, Mankin HJ, Treadwell BV (1985) Stress induced proteins in chondrocytes form patients with osteoarthritis. Arthritis Rheum 28:1140–1145

    Google Scholar 

  17. Van der Zee R, Van Eden W, Meloen RH, Noordzij A, Van Embden JDA (1989) Efficient mapping and characterization of T cell epitopes by the simultaneous synthesis of multiple peptides. Eur J Immunol 19:43–47

    Google Scholar 

  18. Van Eden W, Hogervorst EJM, Hensen EJ, Van der Zee R, Van Embden JDA, Cohen IR (1989) A cartilage mimicking T cell epitope on a 65 kD mycobacterial heat-shock protein: adjuvant arthritis as a model for human rheumatoid arthritis. In: Oldstone MBA (ed) Molecular mimicry: chemical similarity between microbe and host protein as a cause of autoimmunity. Springer, Berlin Heidelberg New York (Current topics in microbiology and immunology), pp 27–43

    Google Scholar 

  19. Kaufmann SHE, Vath U, Thole JER, Van Embden JDA, Emmrich F (1987) Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64 kD protein. Eur J Immunol 17:351–357

    Google Scholar 

  20. Thole JER, Keulen W, Kolk A, Groothuis D, Berwald L, Tiesjema R, Van Embden J (1987) Characterisation, sequence determination and immunogenicity of a 64-kilodalton protein of Mycobacterium bovis BCG, expressed in Escherichia coli K-12. Infect Immun 55:1466–1475

    Google Scholar 

  21. Van Eden W, De Vries RRP, Stanford GL, Rook GAW (1983) HLA-DR3 associated genetic control of response to multiple skin tests with new tuberculins. Clin Exp Immunol 51:207–292

    Google Scholar 

  22. Van Eden W, De Vries RRP (1984) HLA and leprosy: a reevaluation. Lepr Rev 55:89–104

    Google Scholar 

  23. Van Eden W, Elferink BG, Hermans J, De Vries RRP, Van Rood JJ (1984) Role of HLA-class II products in proliferative T lymphocyte responses to PPD: evidence for a regulatory influence associated with MB1. Scand J Immunol 10:503–510

    Google Scholar 

  24. Van Eden W, Holoshitz J, Cohen IR (1986) Autoimmunity and the host-parasite relationship. Clin Immunol Allerg 6:113–126

    Google Scholar 

  25. Ottenhoff THM, Torres P, De Las Aguas JT, Fernandez R, Van Eden W, De Vries RRP, Stanford JL (1986) Evidence for an HLA-DR4-associated immune response gene for Mycobacterium tuberculosis: a clue to the pathogenesis of rheumatoid arthritis. Lancet II:310–313

    Google Scholar 

  26. Palacios-Box AA, Estrada GI, Colston MJ, Panayi GS (1988) HLA-DR4 restricted lymphocyte proliferation to Mycobacterium-tuberculosis extract in rheumatoid arthritis and healthy subjects. J Immunol 140:1844–1850

    Google Scholar 

  27. Holoshitz J, Klajman A, Drucker I, Lapidot Z, Yaretzky A, Frenkel A, Van Eden W, Cohen IR (1986) T-lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage. Lancet II:305–309

    Google Scholar 

  28. Res PC, Schaar CG, Breedveld FC, Van Eden W, Van Embden JDA, Cohen IR, De Vries RRP (1988) Synovial fluid T cell reactivity against 65 kD heat-shock protein of mycobacteria in early chronic arthritis. Lancet II:478–488

    Google Scholar 

  29. Bahr GM, Rook GAW, Al-Saffar M, Van Embden JDA, Stanford JL, Behbehani K (1989) An analysis of antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked high levels of antibody to the 65 kD heat shock protein of M. tuberculosis in rheumatoid arthritis. Clin Exp Immunol 74:211–215

    Google Scholar 

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Authors and Affiliations

  1. Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, NL-3508 TD, Utrecht, The Netherlands

    W. van Eden, E. J. M. Hogervorst & E. J. Hensen

  2. Laboratory of Bacteriology, National Institute for Public Health and Environmental Protection, NL-3720 BA, Bilthoven, The Netherlands

    R. van der Zee & J. D. A. van Embden

  3. Department of Cell Biology, Weizmann Institute of Science, 76100, Rehovot, Israel

    I. R. Cohen

Authors
  1. W. van Eden
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  2. E. J. M. Hogervorst
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  3. R. van der Zee
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  4. J. D. A. van Embden
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  5. E. J. Hensen
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  6. I. R. Cohen
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van Eden, W., Hogervorst, E.J.M., van der Zee, R. et al. The mycobacterial 65 kD heat-shock protein and autoimmune arthritis. Rheumatol Int 9, 187–191 (1989). https://doi.org/10.1007/BF00271878

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