Abstract
We report on a patient with systemic mastocytosis with an activating point mutation of the c-kit gene. This mutation was identical to the c-kit mutation recently described by other groups. Additionally, we found that in this patient the mutation was also present in myeloid and erythroid lineages, indicating a multilineage involvement and suggesting a clonal origin of the disease similar to that described in other myeloproliferative disorders. The erythroid involvement was further demonstrated by the presence of erythropoietin-"independent" erythroid progenitor cells.
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Received: January 9, 1998 / Accepted: June 22, 1998
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Afonja, O., Amorosi, E., Ashman, L. et al. Multilineage involvement and erythropoietin-"independent" erythroid progenitor cells in a patient with systemic mastocytosis. Ann Hematol 77, 183–186 (1998). https://doi.org/10.1007/s002770050439
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DOI: https://doi.org/10.1007/s002770050439