Skip to main content
Log in

Multilineage involvement and erythropoietin-"independent" erythroid progenitor cells in a patient with systemic mastocytosis

  • CASE REPORT
  • Published:
Annals of Hematology Aims and scope Submit manuscript

Abstract

 We report on a patient with systemic mastocytosis with an activating point mutation of the c-kit gene. This mutation was identical to the c-kit mutation recently described by other groups. Additionally, we found that in this patient the mutation was also present in myeloid and erythroid lineages, indicating a multilineage involvement and suggesting a clonal origin of the disease similar to that described in other myeloproliferative disorders. The erythroid involvement was further demonstrated by the presence of erythropoietin-"independent" erythroid progenitor cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: January 9, 1998 / Accepted: June 22, 1998

Rights and permissions

Reprints and permissions

About this article

Cite this article

Afonja, O., Amorosi, E., Ashman, L. et al. Multilineage involvement and erythropoietin-"independent" erythroid progenitor cells in a patient with systemic mastocytosis. Ann Hematol 77, 183–186 (1998). https://doi.org/10.1007/s002770050439

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002770050439

Navigation