GynecologyHuman papillomavirus deoxyribonucleic acid as a prognostic indicator in early-stage cervical cancer: A possible role for type 18☆
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Cited by (50)
Human papillomavirus genotype and prognosis of cervical cancer: Favorable survival of patients with HPV16-positive tumors
2018, Papillomavirus ResearchCitation Excerpt :The current study showed stage-specific results, with the favorable survival effect of HPV16 positivity restricted to FIGO stage III/IV tumors. However, several studies have reported significant associations between HPV18 detection and poor prognosis in early-stage ICC [6,7,11], suggesting rapid spread of HPV18-positive tumors during the early stage. Given that few patients with FIGO stage I/II tumors died from the disease in the present study, our sample size may have been too small to detect any slight differences in survival among early-stage tumors with different HPV genotypes.
Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity
2013, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :The oncogenic HPV types can be classified phylogenetically according to L1 protein sequence homology into α9 (HPV16, -31, -33, -35, -52, -58, and -67) and α7 (HPV18, -39, -45, -59, -68, and -70) classes (5). Several studies have shown HPV18-associated cervical cancer to have a poorer outcome after primary surgery than HPV16-positive tumors and that prognostic significance is retained in multivariate analysis (6-8). For example, in a study of 171 patients with stage Ib-IIa disease who received radical hysterectomy and lymphadenectomy, HPV18 tumors had a poorer prognosis compared with HPV16 in multivariate analysis (hazard ratio [HR] 2.59, 95% confidence interval [CI] 1.08-6.22) (8).
HPV-18 is a poor prognostic factor, unlike the HPV viral load, in patients with stage IB-IIA cervical cancer undergoing radical hysterectomy
2011, Gynecologic OncologyCitation Excerpt :The following factors have been identified as predictors of survival: lymph node metastasis, primary tumor size, depth of stromal invasion, the presence or absence of LVSI, parametrial invasion, histologic cell type, and the status of the vaginal margins [7]. The relationship between HPV genotype to prognosis of early-stage invasive cervical cancer is controversial [11–15]. It has been reported that HPV-18-positive tumors are associated with a poorer prognosis [11–13].
Clinical effect of human papillomavirus genotypes in patients with cervical cancer undergoing primary radiotherapy
2010, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :The presence of HPV DNA has been shown to be essential for the development of invasive cervical cancer (1, 2). However, contradictory results have been presented concerning the influence of HPV genotypes on the clinical outcome of cervical cancer patients (6–9, 11–14, 20). The present study with a large population (1,010 patients) and long-term follow-up (median, 78 months) has illustrated the significant clinical effect of HPV genotypes in cervical cancer patients undergoing primary RT.
How much cervical cancer in Australia is vaccine preventable? A meta-analysis
2008, VaccineCitation Excerpt :Eight studies were excluded (some for more than one reason): seven did not use PCR [23–30], four had too few specimens [23–25,31] and one only tested for HPV16 [32,33]. Five studies were used to assess type specific HPV prevalence in cervical cancers [21,34–37] giving a total of 553 cancers. The study of Chen [38] was not included, as the same specimens have been re-typed in the study of Stevens [21].
Human papillomavirus-16 in oral squamous cell carcinoma: Clinical correlates and 5-year survival
2007, British Journal of Oral and Maxillofacial Surgery
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Supported by the National Health and Medical Research Council of Australia and the Royal Prince Alfred Hospital Cancer Research Fund.