Elsevier

Clinica Chimica Acta

Volume 79, Issue 1, 15 August 1977, Pages 261-263
Clinica Chimica Acta

Short communication
Erum-induced changes in electrophoretic mobility of creatine phosphokinase isoenzymes?

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Abstract

BB isoenzyme of creatine phosphokinase (CK-BB) obtained from human brain-extract changes its electrophoretic mobility after incubation in human serum at 37° C. No change of electrophoretic mobility of CK-BB is observed after incubation in isotonic saline. We have shown by means of immunoprecipitation with specific antibodies that the structure of CK-BB is not changed. These findings are supported by other authors and make the diagnostic value of electrophoretic separation of CK isoenzymes doubtful as after a 3-h incubation CK-BB migrates similarly to CK-MB and consequently may be misinterpreted.

References (4)

  • H. Won Cho et al.
  • Deutsche Gesellschaft für Klinische Chemie

    Z. Klin. Chem. Klin. Biochem.

    (1972)
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