Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells☆
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Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation
2012, Journal of Biological ChemistryCitation Excerpt :Taken together, these results indicated that PI3K activity bound to IGF-IR is necessary for IGF-I-dependent cell cycle progression from G1 phase to S phase. It has been shown that continuous stimulation of cells with IGFs is required for IGF-induced cell proliferation (4–9), and this role of IGFs as a cell cycle progression factor is distinctive from those of many other growth factors. The molecular components of the prolonged signaling pathway were still unclear.
"Competence" Progress
2011, Molecular CellCitation Excerpt :In Balb/c 3T3 cells, the major competence factor in platelet extracts is platelet-derived growth factor (PDGF). Among plasma growth factors, insulin-like growth factor 1 (IGF1, Somatomedin C) and epidermal growth factor (EGF) had progression activity (Stiles et al., 1979), with an optimal progression cocktail containing both (Leof et al., 1982). The discovery that G1 cell-cycle control is embodied by accumulation of cyclins to activate cyclin-dependent protein kinases (CDKs) is one of the great syntheses of 20th century cell biology.
Anchorage-independent growth of fibroblasts that express a truncated IGF-I receptor
2001, Biochemical and Biophysical Research CommunicationsInsulin-like growth factor I-mediated degradation of insulin receptor substrate-1 is inhibited by epidermal growth factor in prostate epithelial cells
2000, Journal of Biological ChemistryCitation Excerpt :In BALB 3T3 cells, there is a temporal requirement for the addition of EGF and IGF-I. EGF must be present prior to IGF-I treatment. If IGF-I is added prior to EGF, and subsequently removed, BALB 3T3 cells do not proceed into S phase (39-43). This information, combined with the results presented here, suggests that one mechanism underlying this cooperation between EGF and IGF-I in prostate epithelial cells is the maintenance of IRS-1 levels.
Potential role of pyrroline 5-carboxylate in regulation of collagen biosynthesis in cultured human skin fibroblasts
2000, Comparative Biochemistry and Physiology - A Molecular and Integrative PhysiologyMolecular markers of IGF-I-mediated mitogenesis
1998, Experimental Cell Research
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This work was supported by NCI grants CA 24193 and CA 16084.
- 1
W. W. was supported by NIH Postdoctoral Fellowship GM 1477.
- 2
W. J. P. was supported by JFRA-32 from the ACS.