Characterization of human p53 antigens employing primate specific monoclonal antibodies
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Current Approaches to Diagnosis and Treatment of Ductal Carcinoma In Situ and Future Directions
2017, Progress in Molecular Biology and Translational ScienceCitation Excerpt :The most common mutations of p53 are missense mutations due to single amino acid changes in the protein and the majority of these are in the region encoding a DNA binding site.194 These mutations result in stabilization and increased half life of the protein resulting in positive staining on immunohistochemistry (IHC).197–199 The accessibility of IHC makes this a common detection method used in studies of breast cancer.
p53 family activities in development and cancer: Relationship to melanocyte and keratinocyte carcinogenesis
2005, Journal of Investigative DermatologyCitation Excerpt :p53 was discovered 25 years ago as a mammalian protein that was targeted for disruption by tumor virus proteins such as SV40 and frequently overexpressed (in a defective form) in human tumors [1–3].
Protéine P53: Sentinelle du génome
1996, Revue Francaise des LaboratoiresDiversity of human p53 mutants revealed by complex formation to SV40 T antigen
1993, European Journal of Cancer
Copyright © 1983 Published by Elsevier Inc.