Elsevier

Virology

Volume 190, Issue 2, October 1992, Pages 654-665
Virology

Genetic relationships between bovine herpesvirus 4 and the gammaherpesviruses epstein-Barr virus and herpesvirus saimiri

https://doi.org/10.1016/0042-6822(92)90903-3Get rights and content

Abstract

The overall arrangement of genes in the unique central part of the bovine herpesvirus type 4 (BHV-4) genome has been deduced by analysis of short DNA sequences. Twenty-three genes conserved in at least one of the completely sequenced herpesviruses have been identified and localized. All of these genes encoded amino acid sequences with higher similarity to proteins of the gammaherpesviruses Epstein-Barr virus (EBV) and herpesvirus saimiri (HVS) than to the homologous products of the alphaherpesviruses varicella-zoster virus and herpes simplex virus type 1 or the betaherpesvirus human cytomegalovirus. The genome organization of BHV-4 had also an overall collinearity with that of the gammaherpesviruses EBV and HVS. Furthermore, the BHV-4 genes content and arrangement were more similar to those of HVS than to those of EBV, suggesting that BHV-4 and HVS are evolutionarily more closely related to each other than either are to EBV. BHV-4 DNA sequences were generally deficient in CpG dinucleotide. This CpG deficiency is characteristic of gammaherpesvirus genomes and suggests that the BHV-4 latent genome is extensively methylated. Despite several biological features similar to those of beta herpesviruses, BHV-4 displays the molecular characteristics of the representative members of the gammaherpesvirinae subfamily.

References (74)

  • R. Baer et al.

    DNA sequence and expression of the B95-8 Epstein-Barr virus genome

    Nature

    (1984)
  • H.H. Barahona et al.

    Herpesvirus aotus type 2: A new viral agent from owl monkeys (Aotus trivirgatus)

    J. Infect. Dis.

    (1973)
  • A.P. Bird

    DNA methylation and the frequency of CpG in animal DNA

    Nucleic Acids Res.

    (1980)
  • W. Bodemer et al.

    Organization of the thymidylate synthase gene of herpesvirus saimiri

    J. Virol.

    (1986)
  • G.W. Bornkamm et al.

    Structure of herpesvirus saimiri genomes: arrangement of heavy and light sequences in the M genome

    J. Virol.

    (1976)
  • A. Bridgen et al.

    Preliminary characterization of the alcelaphine herpesvirus 1 genome

    J. Gen. Virol.

    (1989)
  • M. Bublot et al.

    Bovine herpesvirus 4 genome: Cloning, mapping and strain variation analysis

    J. Gen. Virol.

    (1990)
  • M. Bublot et al.

    Genomic diversity among bovine herpesvirus 4 field isolates

    Arch. Virol.

    (1991)
  • M. Bublot et al.

    Antigenic and genomic identity between simian herpesvirus aotus type 2 and bovine herpesvirus type 4

    J. Gen. Virol.

    (1991)
  • A.E. Buckmaster et al.

    Gene sequence and mapping data from Marek's disease virus and herpesvirus of turkeys: Implications for herpesvirus classification

    J. Gen. Virol.

    (1988)
  • K.R. Cameron et al.

    The 160,000-Mr virion protein encoded at the right end of the herpesvirus saimiri genome is homologous to the 140,000-Mr membrane antigen encoded at the left end of the Epstein-Barr virus genome

    J. Virol.

    (1987)
  • G. Castrucci et al.

    Reactivation in calves of latent infection by Bovid herpesvirus-4

    Microbiologica

    (1987)
  • M.S. Chee et al.

    Analysis of the protein-coding content of the sequence of human cytomegaiovirus strain AD 169

    Curr. Top. Microbiol. Immunol.

    (1990)
  • A.J. Davison et al.

    The complete DNA sequence of varicella-zoster virus

    J. Gen. Virol.

    (1986)
  • A.J. Davison et al.

    Genetic relations between varicella-zoster virus and Epstein-Barr virus

    J. Gen. Virol.

    (1987)
  • J. Devereux et al.

    A comprehensive set of sequence analysis programs forthe VAX

    Nucleic Acids Res.

    (1984)
  • J. Dubuisson et al.

    Comparison of proteins of simian herpesvirus aotus type 2 and bovine herpesvirus type 4

    J. Gen. Virol.

    (1991)
  • S. Efstathiou et al.

    Cloning and molecular characterization of the murine herpesvirus 68 genome

    J. Gen. Virol.

    (1990)
  • S. Efstathiou et al.

    Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri

    J. Gen. Virol.

    (1990)
  • B. Ehlers et al.

    Analysis of bovine cytomegalovirus genome structure: Cloning and mapping of the monomeric polyrepetitive DNA unit, and comparison of European and American strains

    J. Gen. Virol.

    (1985)
  • C.G. Fabricant et al.

    Intracellular and extracellular mineral crystal formation induced by viral infection of cell cultures

    Infect. Immun.

    (1971)
  • D.-F. Feng et al.

    Progressive sequence alignment as a prerequisite to correct phylogenetic trees

    J. Mol. Evol.

    (1987)
  • B. Fleckenstein et al.

    Repetitive sequences in complete and defective genomes of herpesvirus saimiri

    J. Virol.

    (1975)
  • B. Fleckenstein et al.

    Herpesvirus ateles DNA and its homology with herpesvirus saimiri nucleic acid

    J. Virol.

    (1978)
  • D. Given et al.

    DNA of Epstein-Barr virus. V. Direct repeats of the ends of Epstein-Barr virus DNA

    J. Virol.

    (1979)
  • U.A. Gompels et al.

    Conservation of gene organization in the lymphotropic herpesviruses, herpesvirus saimiri and Epstein-Barr virus

    J. Virol.

    (1988)
  • D.G. Higgins et al.

    Fast and sensitive multiple sequence alignments on microcomputer

    C.A.B.I.O.S.

    (1989)
  • Cited by (0)

    Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession Nos. M90768 through M90800.

    2

    Present address: Department of Oncology, Johns Hopkins School of Medicine, 418 North Bond Street, Baltimore, MD 21231.

    View full text