ORIGINAL ARTICLESDetection of three novel mutations in two haemophilia A patients by rapid screening of whole essential region of factor VIII gene
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Cited by (99)
Hemophilia: A practical approach to genetic testing
2005, Mayo Clinic ProceedingsCitation Excerpt :Because of the large size of the factor VIII gene (26 exons), this is a labor-intensive and expensive task; however, availability of automated methods has led to more efficient testing. Alternative strategies include analysis of factor VIII mRNA by reverse transcriptase-PCR37; however, although this is probably less labor intensive, it is likely not practical because of the instability of mRNA, unless the testing is done with a fresh peripheral blood sample that is processed promptly. Direct DNA-based testing provides the most definitive information on carrier status.
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