Elsevier

The Lancet

Volume 341, Issue 8855, 15 May 1993, Pages 1251-1254
The Lancet

REVIEW ARTICLE
Apoptosis and disease

https://doi.org/10.1016/0140-6736(93)91154-EGet rights and content

Abstract

The intercellular connections that characterise advanced forms of life would not be possible without a mechanism to remove individual cells that are no longer needed, or that function abnormally. Such physiological cell death, in the absence of inflammation, is achieved by apoptosis, a structurally distinct programmed cell death pathway. Defective regulation of programmed cell death may play a part in the aetiology of cancer, AIDS, autoimmune diseases, and degenerative diseases of the central nervous system. The pharmacological manipulation of apoptosis offers new possibilities for the prevention and treatment of these illnesses.

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