Research paper
IgG anti-GM1 antibodies from patients with acute motor neuropathy are predominantly of the IgG1 and IgG3 subclasses

https://doi.org/10.1016/0165-5728(94)00190-YGet rights and content
Under a Creative Commons license
open archive

Abstract

Increased titers of IgG anti-GM1 and anti-asialo GM1 (GA1) ganglioside antibodies are present in some patients with the Guillain-Barré syndrome, particularly with the motor axonal variant, and following infection with Campylobacter jejuni or parenteral administration of gangliosides. The subclass distribution of IgG anti-GM1 or GA1 antibodies from 19 patients with acute motor neuropathy and elevated antibody titers were measured by ELISA using mouse monoclonal antibodies specific for human IgG subclasses. The anti-GM1 or GA1 antibodies were predominantly of the IgG1 and IgG3 subclasses, which are capable of complement fixation, and are characteristic of a T cell-dependent antibody response.

Keywords

Anti-GMl antibody
Anti-asialo GM1 antibody
Immunoglobulin G subclass
Acute motor neuropathy
Guillain-Barré syndrome

Cited by (0)

1

Dr. M. Ogino is a Post Doctoral Fellow from Kitasato University, Japan.