Research reportGender-specific impairment on Morris water maze task after entorhinal cortex lesion
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The gist and details of sex differences in cognition and the brain: How parallels in sex differences across domains are shaped by the locus coeruleus and catecholamine systems
2019, Progress in NeurobiologyCitation Excerpt :Perhaps more influential than structural differences on sex differences in behavior, are the observations suggesting there are sex differences in the recruitment of other brain regions during spatial tasks. Lesions of the entorhinal cortex, located in the parahippocampal gyrus and sharing connections with CA1 and CA3, cause greater impairment in males than in females on the Morris water maze (Roof et al., 1993). By contrast, female rats show greater deficits on most measures of a radial maze and Morris water maze tasks when they received frontal cortex lesions (Kolb and Cioe, 1996).
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2018, Physiology and BehaviorCitation Excerpt :Specifically, females are more inclined than males to use landmarks for navigating and males tend to navigate using geometric information and cardinal directions more often than females [11,52]. For example, female rats solve a cued-version of a MWM as well as male rats, but males outperform females in the non-cued version of the maze [40]. It is possible that males and females rely on separate brain regions (i.e., the hippocampus and striatum) to solve different types of spatial navigation tasks.
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