Deletion mapping of the medulloblastoma locus on chromosome 17p
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Primary Tumors of the Nervous System
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2011, Cancer GeneticsCitation Excerpt :The first insights into the potential clinical application of profiling chromosomal aberrations were reported in 1987, in which a report of 4 children identified aneuploidy as a marker of poor prognosis (38). Subsequent karyotype studies of primary medulloblastomas identified other common chromosomal aberrations such as deletion of 6q, deletion of 16q, isochromosome 17q, and deletion of chromosome 17p (39ā44). The presence of the TP53 gene on the short arm of chromosome 17 suggested that this finding was not insignificant, and later studies have suggested that loss of 17p and isochromosome 17q may be negative prognostic markers (45ā48).
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