Organization and nucleotide sequences of the human tyrosinase gene and a truncated tyrosinase-related segment
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Natural tyrosinase enzyme inhibitors: A path from melanin to melanoma and its reported pharmacological activities
2023, Biochimica et Biophysica Acta - Reviews on CancerSite-directed mutagenesis around the CuA site of a polyphenol oxidase from Coreopsis grandiflora (cgAUS1)
2015, FEBS LettersCitation Excerpt :The bulky, monophenolase-blocking phenylalanine (F273 in cgAUS1) is present in most plant PPOs, but in some species leucine is at this position instead of phenylalanine, such as pineapple PPO from Ananas comosus and bread wheat PPO from Triticum aestivum [20]. However, these structurally relevant residues are not found in human and fungal tyrosinases as in Agaricus bisporus or Neurospora crassa and the fungal catechol oxidase from Aspergillus oryzae, but a thioether-forming cysteine is found in fungal tyrosinases at a different sequence location than in plant PPOs (as CXH in abPPO4 and abPPO3; and C(X)16-19H in plant PPOs, see Fig. 2) [8,20–30]. Recently, aurone synthase from C. grandiflora (cgAUS1) was successfully heterologously expressed in Escherichia coli, but recombinant aureusidin synthase (AmAS1) has not been described so far [5,8].
Abnormalities of Pigmentation
2013, Emery and Rimoin's Principles and Practice of Medical GeneticsCloning, characterization and expression of tyrosinase-like gene in amphioxus Branchiostoma japonicum
2013, Fish and Shellfish ImmunologyCitation Excerpt :In the present study, the calculated molecular mass of the AmphiTYR were 60.9 kDa. It is close to the mass (60.3–61.2 kDa) of vertebrate tyrosinase including human, chicken, mouse, cattle and fish [14,31–34], but different from the invertebrate phenoloxidase cloned from shrimps, mud crab and freshwater crayfish with 76–80.7 kDa [35–37]. Sequence data suggested that AmphiTYR had higher similarity with vertebrate tyrosinase than to invertebrate phenoloxidase.
Next-generation DNA re-sequencing identifies common variants of TYR and HLA-A that modulate the risk of generalized vitiligo via antigen presentation
2012, Journal of Investigative DermatologyTyrosinase gene mutations in the Chinese Han population with OCA1
2014, Genetics Research