PaperExpression of glutathione-S-transferase-π in human tumours
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Cited by (40)
Proteomics identification of azaspiracid toxin biomarkers in blue mussels, Mytilus edulis
2009, Molecular and Cellular ProteomicsCitation Excerpt :By far the most studied function of the GST enzymes is their role in cellular detoxification (52) primarily against oxygen free radicals and peroxides produced by physiological cellular processes and exogenous stimuli. GST Pi has implications for human health where overexpression has been associated with carcinogenesis and is used as a tumor marker for gastrointestinal malignancies (53–56). The above observations would thus now indicate that AZAs could pose a considerable health risk to vertebrate and non-vertebrate animals following their consumption.
Glutathione S-transferase: differential expression of α, μ, and π isoenzymes in benign prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinoma
2007, Human PathologyCitation Excerpt :This finding stands in contrast with most other cancers in which GST expression is increased, often markedly so, compared with benign tissue. For example, there is increased expression of GSTπ in cancers of the breast, colon, stomach, pancreas, bladder, lung, head and neck, ovary, and cervix, as well as soft tissue sarcoma, testicular embryonal carcinoma, meningioma, and glioma [8-18]. Selective down-regulation of GSTα and μ subclasses was observed in some cancers despite the increased expression of GST π (eg, colonic and renal cell carcinoma) [19,20].
Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition
2004, Biochemical PharmacologyCitation Excerpt :GSTP1-1 is a phase II drug metabolism enzyme playing an important role in cell detoxification by conjugating electrophilic compounds to glutathione, allowing their export through the GS-X pump [2]. However, it is also implicated in carcinogenesis [3–7] and development of anti-cancer drug resistance [8–11]. Indeed, GSTP1-1 over-expression is associated with cisplatin resistance in head and neck squamous cell carcinoma [12] and with poor prognosis in breast cancer [13].
Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells
2004, Biochemical PharmacologyCitation Excerpt :In leukemic lineages, studies of the expression and the activity of GST isoenzymes revealed that the human Pi class GST isoform (GSTP1-1) is the most represented, particularly in U937, K562 and Jurkat cells [9]. GSTP1-1 is commonly increased in many tumors [10–14] and involved in the development of antineoplastic drug resistance [15–18]. Interestingly, GSTP1-1 has been shown to be involved in preventing apoptosis in hematopoietic cells [19] and to protect against H2O2-induced cell death via the coordinated regulation of stress kinases [20].