Structure
Research articleMajor antigen-induced domain rearrangements in an antibody
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Cited by (215)
The Role of the Constant Region in Antibody-Antigen Interactions: Redefining the Modular Model of Immunoglobulin Structure
2018, Structural Biology in Immunology: Structure and Function of Novel Molecules of Immunologic ImportanceConformational heterogeneity in antibody-protein antigen recognition: Implications for high affinity protein complex formation
2014, Journal of Biological ChemistryCitation Excerpt :Changes in the conformations and dynamics of the CDR3 loops induced by antigen binding appear to be accompanied by reorientations of the antibody variable domains relative to each other, with significant chemical changes seen for residues at the VH/VL interface in both the anti-IL-1β Fab and anti IL-6 scFv (Figs. 6 and 7). A number of previous studies have reported antigen-induced changes in the orientation of the variable domains; however, no consistent picture has emerged (34–37). This may reflect the difficulty in detecting significant but small structural changes in proteins, which can now be reliably identified for relatively large proteins and complexes through the high sensitivity of backbone and side chain NMR chemical shifts to changes in conformation (6–9, 14, 15, 38).
From DARPins to LoopDARPins: Novel LoopDARPin design allows the selection of low picomolar binders in a single round of ribosome display
2014, Journal of Molecular BiologyCitation Excerpt :Nonetheless, structural analysis of different CDR-H3 loops identified common structural patterns within the basis of the loop, although the tip of the loop differed considerably [23,35]. Interestingly, the CDR-H3 loop plays a crucial role in antigen recognition [36,37], sometimes by changing its conformation upon binding [38–40]. The success of the original DARPin design in routinely generating highly specific binders against a multitude of targets with very different properties has been demonstrated in numerous studies [4–6].
Geometric Epitope and Paratope Prediction
2023, bioRxivGeometric Epitope and Paratope Prediction
2023, arXivStructural mechanism of Fab domain dissociation as a measure of interface stability
2023, Journal of Computer-Aided Molecular Design
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Present address: Teijin Institute for Bio-Medical Research, Teijin Limited, 4-3-2 Asahigaoka, Hino, Tokyo 191, Japan