Prognostic value of TP53 and K-ras-2 mutational analysis in stage III carcinoma of the colon
References (26)
- et al.
Survival and acquired genetic alterations in colorectal cancer
Gastroenterology
(1992) - et al.
Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer
Gastroenterology
(1993) - et al.
Molecular mechanisms involved in tumorigenesis and their surgical implications
Am J Surg.
(1994) - et al.
Stability of K-ras mutations through-out the natural history of human colorectal cancer
Eur J Cancer
(1992) - et al.
The role of the H-ras oncogene in radiation resistance and metastasis
Int J Radiat Oncol Biol Phys.
(1990) - et al.
Genetic alterations during colorectal tumor development
NEJM
(1988) - et al.
Independent prognostic value of ploidy in colorectal cancer: a prospective study using image cytometry
Cancer
(1990) - et al.
Flow cytometric DNA index in the prognosis of colorectal cancer
Cancer
(1991) - et al.
Comparison of double and single parameters in DNA analysis for staging and as a prognostic indicator in patients with colon and rectal carcinoma
Dis Colon Rectum
(1994) - et al.
Allelic loss of chromosome 18q and prognosis in colorectal cancer
NEJM
(1994)
Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers
Oncogene
Cytoplasmic accumulation of p53 protein: an independent prognostic indicator of colorectal adenocarcinomas
J Natl Cancer Inst.
Determination of tumor aggressiveness in colorectal cancer by K-ras-2 analysis
Arch Surg.
Cited by (76)
Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13
2015, GenomicsCitation Excerpt :However, monoclonal anti-EGFR antibodies are sometimes ineffective against metastasis derived from CRC even when the primary CRC has wild-type K-ras, which might be due to differences between primary CRCs and the corresponding metastatic tumors with regard to K-ras mutational status. Some studies of the relationship between K-ras gene mutations and various clinicopathological characteristics have been conducted, but the results remain inconclusive [9–12]. To clarify the relationship between K-ras gene mutations and the prognosis for patients with colorectal cancer, it was necessary to perform a systematic review and meta-analysis of the published studies to derive a more precise estimation [13], where the associations of the prognostic significance for patients with mutations at codon 12 become nonsignificant after adjusting for the effect of publication bias, while K-ras mutations at codon 13 are associated with poorer overall survival.
Mutant KRAS, chromosomal instability and prognosis in colorectal cancer
2005, Biochimica et Biophysica Acta - Reviews on CancerPredictive and prognostic genetic markers in colorectal cancer
2004, Seminars in Colon and Rectal SurgeryThe genetics of sporadic colon cancer
2004, Seminars in Colon and Rectal SurgeryColorectal cancer: Prognostic molecular markers
2004, Gastroenterologie Clinique et Biologique