Short communicationHuman recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease
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Acknowledgements
This work was supported by NIH Grants (AG05131 and AG10689) and the Yamanouchi Pharmaceutical. We thank Drs. Leon Thal, Robert Katzman, and Makoto Yoshimoto for their continuous encouragement.
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2021, Journal of Biological ChemistryCitation Excerpt :These results demonstrated that the formation of the αSyn–FABP3 complex in cells results in an increase in cytotoxicity that is sensitive to perturbations that focus on the C-terminal region of αSyn. The deposition of Lewy bodies, composed of αSyn aggregates, in neurons is considered to be an important event in the progression of PD (44–46). Many studies have demonstrated that a multitude of cellular factors contribute to this intracellular deposition of αSyn (47, 48).
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