Original ArticlesAngiogenesis in early-invasive and low-malignant-potential epithelial ovarian carcinoma
Section snippets
Methods
Angiogenesis was studied in ovaries of consecutive women who had surgical staging for stage I invasive and low-malignant-potential epithelial ovarian carcinoma between January 1, 1984, and July 1, 1998, at the State University Hospital Health Science Center at Brooklyn, and Kings County Medical Center, Brooklyn, New York. Stage was determined according to International Federation of Gynecology and Obstetrics (FIGO).17 Women diagnosed with epithelial ovarian carcinoma had extended FIGO surgical
Results
Ovarian specimens of 49 consecutive women were stained immunohistochemically for factor VIII–related antigen. The antifactor VIII–related antigen stained the vascular endothelial cells brown, as in typical fields from cases of stage I invasive (Figure 1) and low-malignant-potential epithelial ovarian carcinoma (Figure 2). Microvessel counts according to substage of disease, tumor histopathology, and tumor grade are presented in Table 1. Microvessel counts of women with invasive carcinoma
Discussion
We found that invasive ovarian epithelial carcinoma is associated with statistically significant increased angiogenesis compared with low-malignant-potential disease. In low-malignant-potential tumors, microvessel counts in stroma underlying normal epithelium were statistically significantly lower than those underlying the low-malignant-potential epithelium, which indicates that the angiogenic switch occurs between benign ovarian epithelium and low-malignant-potential disease. Therefore,
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