High titers of antibodies to two human polyomaviruses, JCV and BKV, correlate with increased frequency of chromosomal damage in human lymphocytes
References (28)
- et al.
Analysis of multiaberrant cells in lymphocytes of persons living in different ecological regions
Mutat. Res.
(1994) - et al.
Considerations for population monitoring using cytogenetic techniques
Mutat. Res.
(1988) Oncogenic conversion of transcription factors by chromosomal translocations
Cell
(1991)- et al.
DNA damage, oncogenesis and the p53 tumour-suppressor gene
Mutat. Res.
(1994) Viral persistence
Cell
(1989)- et al.
Cultivation of papova-like virus from human brain with progressive multifocal leukoencephalopathy
Lancet
(1971) - et al.
SV40 T antigen induced chromosomal changes reflect a process that is both clastogenic and aneuploidogenic and is ongoing through neoplastic progression of human fibroblasts
Mutat. Res.
(1992) - et al.
Chromosome aberrations in inhabitants of Byelorussia: consequence of the Chernobyl accident
Mutat. Res.
(1993) - et al.
Cytogenetic ‘rogue’ cells: what is their frequency, origin, and evolutionary significance?
- et al.
Chromosome aberrations among Yanomama Indians
The papovaviruses: general properties of polyoma and simian virus 40
Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues
J. Infect. Dis.
Structure and function of Simian Virus 40 large tumor antigen
Annu. Rev. Biochem.
Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic study group on the health risk of chromosome damage
Cancer Res.
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Lymphocytes with multiple chromosomal damages in a large cohort of West Siberia residents: Results of long-term monitoring
2016, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisCitation Excerpt :The hypothesis about RCs as a cytological effect of a failure in the cell cycle control process and abnormal apoptosis was also suggested [4]. However, many investigations performed in human populations from different countries have not shown a significant relationship between the phenomenon of RCs and contagious diseases [1–10]. Reports on RC frequency in control groups in comparison with groups exposed by well-known clastogens are contradictory [11–14].
Alterations of DNA damage repair pathways resulting from JCV infection
2007, VirologyCitation Excerpt :JCV is mutagenic for established cultured cell lines and human peripheral blood lymphocytes (Theile and Grabowski, 1990). Antibody titers to JCV have been correlated to chromosomal aberrations occurring in lymphocytes (Lazutka et al., 1996; Neel et al., 1996) and JCV infection of human colonic cells induces chromosomal instability and changes in ploidy (Ricciardiello et al., 2003). In the case of PML, stoichiometric analysis of cellular DNA content using the Feulgen technique indicated the occurrence of hyperploidy in inclusion-bearing oligodendrocytes and bizarre astrocytes (Ariza et al., 1996).
Human polyomaviruses and brain tumors
2005, Brain Research ReviewsSomatic evolution of cancer cells
2005, Seminars in Cancer Biology