Human brain cytochrome P450 1B1: immunohistochemical localization in human temporal lobe and induction by dimethylbenz(a)anthracene in astrocytoma cell line (MOG-G-CCM)
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Breaking through the barrier: Modelling and exploiting the physical microenvironment to enhance drug transport and efficacy
2022, Advanced Drug Delivery ReviewsCitation Excerpt :CYP enzymes play a key role in drug metabolism, so their upregulation might indicate neuroprotective system formation. Some of them, like CYP1B1, have been found in the human BBB in vivo [54], though expression varies from one individual to another. Interestingly, the presence of CYP3A4, which was upregulated in the in vitro study of Cucullo et al., was not found in the BBB in vivo [47].
Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic drugs on CYP1 expression in MOG-G-CCM cells
2020, Life SciencesCitation Excerpt :In the present study, we demonstrated that a variety of CYP isoforms, including CYP1B1 and CYP1A1, are expressed in human astrocytoma MOG-G-CCM cells. It has been reported that CYP1B1 and CYP1A1 are expressed in MOG-G-CCM cells [37–39]. To our knowledge, however, this is the first study to show the expression of many CYP isoforms other than CYP1B1 and CYP1A1 in this cell line.
Biochemical and biophysical study of chemopreventive and chemotherapeutic anti-tumor potential of some Egyptian plant extracts
2019, Biochemistry and Biophysics ReportsCitation Excerpt :These products can attack cellular targets, thereby inducing carcinogenicity [32]. Breast tissue may be a major target for the toxicological effects of a variety of lipophilic carcinogens such as polycyclic aromatic hydrocarbon (PAH), if such compounds are not biotransformed to hydrophilic metabolites that are easily excretable [33]. Numerous studies have shown that 7,12-dimethylbenz(a)anthracene (DMBA), a member of the PAH family, can be used to induce experimental breast carcinomas in experimental animals and that this process involves disruption of tissue redox balance; in turn, this suggests that biochemical and pathophysiological disturbances may result from oxidative damage [34,35].
Effect of β-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig
2009, ToxicologyCitation Excerpt :In human, CYP1B1 mRNA was detected in cortex, cerebellum, hippocampus, midbrain, thalamus and, at higher levels, in putamen (Rieder et al., 1998). By an immunohistochemistry assay, CYP1B1 protein was also localized in the human blood–brain interfaces (Rieder et al., 2000). Activation of AhR can also increase the expression of Nrf2 (nuclear E2-related factor 2), a transcription factor involved in the protection against oxidative stress that is present in organs devoted to drug metabolism and detoxification (liver, kidney, and gut) or exposed to the environment (skin, lung, and GI tract) (Miao et al., 2005).
Cytochrome P450-catalyzed pathways in human brain: Metabolism meets pharmacology or old drugs with new mechanism of action?
2007, Pharmacology and Therapeutics