β-catenin: a key mediator of Wnt signaling

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Abstract

β-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. β-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of β-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in β-catenin and in components regulating its stability can contribute to the formation of certain tumors.

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